Impact of reaction products on the Grignard reaction with silanes and ketones |
| |
Authors: | Dmitri Panov Binh T Nguyen |
| |
Institution: | Institute of Organic and Bioorganic Chemistry, University of Tartu, Tartu 51014, Estonia |
| |
Abstract: | Grignard reactions with alkoxysilanes or carbonyl compounds produce alkoxymagnesium halides as by-products. Kinetic measurements for reactions of silanes and of a ketone were performed with Grignard reagents, enriched in alkoxymagnesium halides and taken in a great excess.The alkoxide-type reaction products complex tightly with Grignard reagents and enhance in this way their nucleophilicity, thus accelerating the reaction. However, alkoxides branched at α-C atom exert an unfavorable steric hindrance to reaction resulting in a decrease in the reaction rate. |
| |
Keywords: | Grignard reaction Ketones Kinetics Magnesiumalkoxides Silanes |
本文献已被 ScienceDirect 等数据库收录! |