On the reaction of 4-substituted trimethyltin aromatics with perchlorylfluoride |
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Authors: | Achim Hiller Jörg T Patt Jörg Steinbach |
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Institution: | Institute of Interdisciplinary Isotope Research, Radiopharmacy, Permoserstrasse 15, D-04318 Leipzig, Germany |
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Abstract: | To evaluate the suitability of 18F]perchorylfluoride 18F]FClO3 as an electrophilic fluorination agent for the preparation of radiopharmaceuticals, the reactivity non-radioactive FClO3 towards 4-substituted trimethyltin aromatic compounds was studied. Contrary to the expectation, an electrophilic fluorination of the aromatic nucleus did not occur. The reaction of perchlorylfluoride with aromatic trimethylstannyl compounds resulted in the formation of trimethyltin fluoride and the respective destannylated aromatics in variable yields. |
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Keywords: | Aryl stannanes Perchlorylfluoride Fluorination Electrophilic substitution |
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