Substituent electronic effects in chiral ligands for asymmetric catalysis |
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Authors: | Susan P. Flanagan |
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Affiliation: | Centre for Synthesis and Chemical Biology, UCD School of Chemistry and Chemistry Biology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland |
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Abstract: | The majority of reports of ligand modification for catalysis have followed from systematic variation of the spatial demands of the catalyst. The focus of this review is to highlight selected major contributions to the area of substituent controlled electronic-tuning of some well known chiral ligands and the subsequent effect of these changes during asymmetric catalysis. The ligand types discussed include the salens, phosphites and phosphoramidites, ferrocene-containing ligands, oxazolines and axially chiral ligands. For each ligand type we attempt analyse the effect of systematic variation of electronics and note whether any improvements in catalyst activity and selectivity are obtained. |
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