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Palladium-catalyzed three-component coupling reaction of organic halides, norbornadiene and terminal alkynes
Authors:Yu-Cheng Chang
Institution:Department of Applied Chemistry, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan, ROC
Abstract:A three-component coupling reaction of organic halides, including aryl halides, methyl iodine, alkenyl iodine and bromoalkynes, with norbornadiene and terminal alkynes catalyzed by a palladium complex and a phase transfer agent in the presence of aqueous NaOH gave 5,6-disubstituted norbornene derivatives in good yields.
Keywords:Multi-component reaction  Norbornadiene  Bromoalkyne  Terminal alkyne  Dialkynyl norbornene
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