Synthesis of novel bioactive phthalimido-4-methyl pentanoateorganotin(IV) esters with spectroscopic investigation

The synthesis of monomer, dimer, tricyclohexyl- and triphenyl-tin(IV) complexes with phthalimido-4-methyl pentanoic acid (PMPA) are described and characterized by FT IR, CHN analyzer, ¹H, ¹³C ¹¹⁹Sn NMR and ^119mSn Mössbauer spectroscopic techniques. In vitro ED₅₀, anti-tumor (phytotoxic), anti-yeast, blood pressure and heart rate effect, and bactericidal, fungicidal as well as analgesic bioassays of complexes are also be carried out. The ligand (PMPA) shows excellent analgesic activity while the dimer exhibit strong biocidal and excellent anti-tumor behavior besides of tri-organotin(IV) complexes.