New metallocene-bridged cyclodextrin dimer: A stable derivative of the antitumor drug titanocene dichloride and its potent cytotoxity against human breast cancer (MCF-7) cells |
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| Authors: | Zhenda Lu Qingjin Meng |
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| Institution: | a Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu 210093, PR China
b Department of chemistry, Anqing Normal University, Anqing 246003, PR China |
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| Abstract: | A novel cyclodextrin dimer bridged with titanocene moiety, titanocene dimono6-deoxy-6-(2-(thio-1,2-dicyane ethylenylthio)ethyl thio-1,2-dicyane ethylenylthio)]-β-cyclodextrin] (6), has been synthesized and characterized by IR spectroscopy, UV spectroscopy, thermogravimetry, MALDI-TOF MS spectrum, 1H and 13C NMR spectroscopy. Especially, its potent cytotoxity against Human Breast Cancer (MCF-7) has also been studied. |
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| Keywords: | Titanocene di[mono[6-deoxy-6-(2-(thio-1 2-dicyane ethylenylthio)ethyl thio-1 2-dicyane ethylenylthio)]-β-cyclodextrin] Titanocene complex β-Cyclodextrin dimer Cytotoxity |
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