A high performance method for thermodynamic study on the binding of human serum albumin with erbium chloride期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A high performance method for thermodynamic study on the binding of human serum albumin with erbium chloride

Authors:	G. Rezaei Behbehani A. Divsalar A. A. Saboury F. Faridbod M. R. Ganjali

Affiliation:	(1) Chemistry Department, Imam Khomeini International University, Qazvin, Iran;(2) Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran;(3) Department of Biological Sciences, Tarbiat Moallem University, Tehran, Iran;(4) Departments of Chemistry, University of Tehran, Tehran, Iran

Abstract:	Thermodynamics of the interaction between erbium(III) chloride, Er³⁺, with human serum albumin (HSA), was investigated at pH 7.0 and in phosphate buffer by isothermal titration calorimetry. Our recently, solvation model was used to reproduce the enthalpies of HSA interaction by Er³⁺ over a broad range of metal ion concentration. The solvation parameters recovered from our new model, attributed to the structural change of HSA and its biological activity. The binding parameters for the interaction of Er³⁺ and HSA indicate that the concentrations of Er³⁺ have no significant effects on the structure of HSA.

Keywords:	erbium(III) chloride human serum albumin isothermal titration calorimetry
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