Synthesis of dysideaproline E using organocatalysis |
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Authors: | Owusu-Ansah Ernest Durow Amanda C Harding John R Jordan Angela C O'Connell Susan J Willis Christine L |
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Institution: | School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK BS8 1TS. |
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Abstract: | (S)-4,4-Dichloro-3-methylbutanoic acid was prepared in 51% overall yield from commercially available starting materials using an organocatalytic transfer hydrogenation to 4,4-dichloro-3-methylbut-2-enal in the key step. The (S)-dichloro acid was used as an intermediate in the first total synthesis of dysideaproline E and a diastereomer confirming the structure of the natural product. |
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