Novel mucoadhesive carriers based on alginate-acrylamide hydrogels for drug delivery |
| |
| Affiliation: | A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 119991 Moscow, Russian Federation |
| |
| Abstract: | New mucoadhesive two-component carriers for drug delivery based on synthetic acrylamide/diethylacrylamide and natural alginate hydrogels have been synthesized. The introduction of sodium alginate into polyacrylamide/ poly(diethylacrylamide) gels, followed by their crosslinking with metal ions, significantly changed structure and properties of hydrogels, such as swelling degree, drug capacity and drug release rate in physiological solution. The structure of the gels was characterized by FTIR spectroscopy and scanning electron microscopy. |
| |
| Keywords: | two-component hydrogel interpenetrating networks polyacrylamide poly(N N-diethylacrylamide) sodium alginate covalent network ionic network drug delivery system |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
