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(E)-3-Arylidene-4-diazopyrrolidine-2,5-diones conveniently elaborated into cytotoxic compounds bearing primary sulfonamide and Michael acceptor moieties |
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| Affiliation: | 1. Institute of Chemistry, St. Petersburg State University, 199034 St. Petersburg, Russian Federation;2. Medicinal Chemistry Center, Togliatti State University, 445020 Togliatti, Russian Federation;3. Immanuel Kant Baltic Federal University, 236016 Kaliningrad, Russian Federation |
| Abstract: | The earlier described (E)-3-arylidene-4-diazopyrrolidine-2,5-diones have been elaborated into two distinct series of compounds both bearing a primary sulfonamide moiety and an electrophilic ‘Michael acceptor’ motif. These compounds demonstrated cytotoxicity against colorectal cancer cell line HCT 116. |
| Keywords: | Rhodium catalysis Diazo coupling Sulfonamides Michael acceptors Enzyme inhibitors MTT assay Cell viability Anti-proliferative agents |
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