Iron(iii) chloride-catalyzed mechanochemical cascade synthesis of highly-substituted pyrrolyl indoles |
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| Affiliation: | 1. Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russian Federation;2. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620137 Ekaterinburg, Russian Federation;3. Department of Chemistry, Visva-Bharati University, 731235 Santiniketan, India |
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| Abstract: | Iron(iii) chloride has been found to serve as an efficient catalyst for a mechanochemical (ball milling) one-pot four- component cascade reaction of phenyl glyoxal, anilines, indoles and activated alkyne affording highly-substituted 3-(1H-pyrrol-2-yl)-1H-indoles. The procedure is beneficial because of mild conditions, easily available starting materials, cheap catalyst and possibility for scaling. |
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| Keywords: | ball milling mechanochemical reactions multicomponent reactions cascade reactions indoles gram-scale synthesis |
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