Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells |
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| Affiliation: | 1. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. Institute of Biological Sciences, University of Rostock, D-18059 Rostock, Germany |
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| Abstract: | Immunofluorescent microscopy of cancer cells A549 treated with novel alicyclic (mostly bridged) podophyllotoxin C4-esters at different concentrations gave evidence that the ‘curling’ of microtubules occurred at one of the first steps of their depolymerisation. Molecular dynamics study revealed the differences in curved conformations of tubulin dimer in a complex with adamantane-comprising ester and in a complex with podophyllotoxin. |
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| Keywords: | Molecular dynamics Podophyllotoxin Alicyclic compounds Esters Bridged moieties Tubulin Microtubules Human lung carcinoma A549 Immunofluorescence microscopy |
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