Synthesis of 5-methylidene-2-thio- and 2-selenohydantoins from isothiocyanates or isoselenocyanates and l-serine |
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Institution: | Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation |
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Abstract: | 3-Aryl-5-methylidenethiohydantoins and 3-aryl-5-methylidene-selenohydantoins were obtained by one-pot reaction of aryl isothiocyanates or isoselenocyanates with l-serine in NaOH–H2O–Py mixture followed by room temperature HCl-promoted dehydration. |
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Keywords: | 2-thiohydantoins 2-selenohydantoins exocyclic C=C bond dehydration isothiocyanates isoselenocyanates l-serine |
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