| Synthesis and Bioactivity of Novel Aminomethyl-2-（1, 2,4-triazol）-4, 4-dimethyl-3-pentanone （ol） |
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| 作者姓名： | ShuoWenWANG BoJieSHI YuChangLI QingMinWANG RunQiuHUANG |
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| 作者单位： | ResearchInstituteofElemento-OrganicChemistry,StateKeyLaboratoryofElemento-OrganicChemistry,NankaiUniversity,Tianjin300071 |
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| 摘 要： | 3, 3-Dimethyl-1-(1,2,4-triazol)-2-butanone was treated with aqueous formaldehyde to give an additional product, and subsequent elimination by acetic anhydride yielded 4,4-dimethyl-2-(1,2,4-triazol)-1-penten-3-one. Further addition with substituted amines provideda series of (1,2,4-triazol)-4,4-dimethyl-3-pentanone, which were then reduced by KBH4 to obtaina series of (1,2,4-triazol)-4,4-dimethyl-3-pentanol. Their structures were confirmed by ^1HNMR and elemental analysis. The results of bioassay showed that the title products possess good fungicidal activities.
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| 关 键 词： | 氨甲基-2-（1，2，4-三唑）-4 4-二甲基-3-戊酮 抗真菌药 合成 生物活性 |
Synthesis and Bioactivity of Novel Aminomethyl-2-(1, 2, 4-triazol)-4, 4-dimethyl-3-pentanone (ol) |
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| ShuoWenWANG BoJieSHI YuChangLI QingMinWANG RunQiuHUANG.Synthesis and Bioactivity of Novel Aminomethyl-2-(1, 2, 4-triazol)-4, 4-dimethyl-3-pentanone (ol)[J].Chinese Chemical Letters,2004,15(3):261-264. |
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| Authors: | Shuo Wen WANG Bo Jie SHI Yu Chang LI Qing Min WANG Run Qiu HUANG Research Institute of Elemento-Organic Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin |
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| Institution: | Shuo Wen WANG*,Bo Jie SHI,Yu Chang LI,Qing Min WANG,Run Qiu HUANG Research Institute of Elemento-Organic Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071 |
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| Abstract: | Dimethyl-1-(1, 2, 4-triazol) -2- butanone was treated with aqueous formaldehyde to give an additional product, and subsequent elimination by acetic anhydride yielded 4, 4-dimethyl-2-(1, 2, 4-triazol)-1-penten-3-one. Further addition with substituted amines provided a series of (1, 2, 4-triazol)-4, 4-dimethyl-3-pentanone, which were then reduced by KBH4 to obtain a series of (1, 2, 4-triazol)-4, 4-dimethyl-3-pentanol. Their structures were confirmed by 1HNMR and elemental analysis. The results of bioassay showed that the title products possess good fungicidal activities. |
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| Keywords: | Triazol)-4 4-dimethyl-3-pentanone (1 2 4-triazol)-4 4-dimethyl-3-pentanol synthesis fungicidal activities |
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