Quantitative measurement of molecular diffusion coefficients by NMR spectroscopy |
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Authors: | Zhang Shanmin |
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Affiliation: | Sealy Center for Structural Biology, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1157, USA. shanminz@hotmail.com |
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Abstract: | An offset-independent adiabatic inversion pulse is used in the diffusion experiment to uniformly excite a sample region that is sufficiently long to ignore the ending effects, yet is short enough to have a homogeneous RF field and to represent the pulsed field gradient with a linear approximation. Under these conditions, the diffusion decay of the peak intensity appears to be Gaussian as a function of the effective gradient field ge as if all the molecules inside the selected region experienced the same ge. Quantitative measurement of molecular diffusion coefficients is therefore made possible. |
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