| Direct Observation of Non-covalent Complexes for Phosphorylated Flavonoid-protein Interaction by ESI |
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| 作者姓名： | XiaoLanCHEN TingZHANG HongXiaLIU LingBoQU YouZhuYU YuFenZHAO |
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| 作者单位： | [1]DepartmentofChemistry,ZhengzhouUniversity,Zhengzhou450052 [2]TheKeyLaboratoryforBioorganicPhosphorusChemistry,DepartmentofChemistrySchoolofLifeSciencesandEngineering,TsinghuaUniversity,Beijing100084 |
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| 摘 要： | Diethyl flavon-7-yl phosphate was synthesized by modified Atheron-Todd reaction. The result of ESI shows that the phosphated flavonoids possess stronger binding affinities toward proteins such as myoglobin, insulin and lysozyme and are easier to form the non-covalent complexes with them.
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| 关 键 词： | 非共价联合体 磷酸化 类黄酮 蛋白质 交互作用 ESI |
Direct Observation of Non-covalent Complexes for Phosphorylated Flavonoid-protein Interaction by ESI |
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| XiaoLanCHEN TingZHANG HongXiaLIU LingBoQU YouZhuYU YuFenZHAO.Direct Observation of Non-covalent Complexes for Phosphorylated Flavonoid-protein Interaction by ESI[J].Chinese Chemical Letters,2004,15(3):343-346. |
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| Authors: | Xiao Lan CHEN Ting ZHANG Hong Xia LIU Ling Bo QU You Zhu YU Yu Fen ZHAO |
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| Institution: | Xiao Lan CHEN1,Ting ZHANG 1,Hong Xia LIU 1,Ling Bo QU1*,You Zhu YU1,Yu Fen ZHAO1,2 * 1 Department of Chemistry,Zhengzhou University,Zhengzhou 450052 2 The Key Laboratory for Bioorganic Phosphorus Chemistry,Department of Chemistry School of Life Sciences and Engineering,Tsinghua University,Beijing 100084 |
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| Abstract: | Diethyl flavon-7-yl phosphate was synthesized by modified Atheron-Todd reaction. The result of ESI shows that the phosphated flavonoids possess stronger binding affinities toward proteins such as myoglobin, insulin and lysozyme and are easier to form the non-covalent complexes with them. |
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| Keywords: | DEPH 7-hydroxyflavone phosphorylation ESI-MS myoglobin hen egg white lysozyme (HEWL) bovine insulin non-covalent complexes |
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