Spectrofluorimetric Determination of Methyl Paraben in Pharmaceutical Preparations by Means of its Dansyl Chloride Derivative |
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Authors: | Carmen Cruces-Blanco Antonio Segura Carretero Silvia Fernández Peinado Alberto Fernández Gutiérrez |
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Institution: | (1) Department of Analytical Chemistry, Faculty of Sciences, University of Granada, 18071 Granada, Spain, ES |
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Abstract: | A spectrofluorimetric method for the determination of methyl paraben based on derivatization with the labelling reagent dansyl
chloride (DNS-Cl), is presented. The effect of the reaction variables (pH, DNS-Cl concentration, temperature, reaction time)
and instrumental parameters, has been examined. A linear calibration graph in the ng/ml range has been established. The limit
of detection is 18 ng/ml with relative standard deviation less than 3%. The proposed method has been satisfactorily applied
to determination of the paraben in two pharmaceutical preparations.
Received May 25, 1999. Revision October 20, 1999. |
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Keywords: | : Methyl paraben dansyl chloride fluorimetric determination pharmaceutical preparations |
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