Organic solvent-free, enantio- and diastereoselective, direct Mannich reaction in the presence of water |
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| Authors: | Hayashi Yujiro Urushima Tatsuya Aratake Seiji Okano Tsubasa Obi Kazuki |
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| Institution: | Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp |
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| Abstract: | An organocatalyst-mediated, asymmetric Mannich reaction in the presence of water without using organic solvents has been developed. A highly reactive siloxytetrazole hybrid catalyst has been developed for the reaction of dimethoxyacetaldehyde, while the sodium salt of siloxyproline is an effective catalyst of alpha-imino glyoxylate. Excellent enantioselectivity can be realized, and the usage of organic solvents can be reduced compared to the conventional reactions in organic solvents. |
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