Organelle targetable fluorescent probes for hydrogen peroxide |
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| Affiliation: | 1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China;2. Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China;1. College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China;2. College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China;1. Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 210009, China;2. Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, 21201, USA |
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| Abstract: | Hydrogen peroxide(H_2 O_2), as important products of oxygen metabolism, plays an important role in many biological processes, such as immune responses and cellular signal transduction. However, abnormal production of H_2 O_2 can damage cellular biomolecules, which was closely associated with many diseases.Thus, it is urgent to monitor the level change of H_2 O_2 in living cells, particularly at subcellular levels.Toward this end, a wide variety of H_2 O_2 fluorescent probes have been designed, developed and applied for imaging of H_2 O_2 in subcellular levels. In this review, we highlight the representative cases of H_2 O_2 fluorescent probes with mitochondria, nuclei and lysosomes-targetable ability. The review contains organelle target strategies, structures, fluorescence behavior and biological applications of these probes. |
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| Keywords: | Hydrogen peroxide Fluorescence probes Mitochondria target Nuclei target Lysosomes target Living cells |
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