| Microwave-prompted rapid and efficient synthesis of 3-alkyl substituted imidazo[1,5-a]pyridines |
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| 引用本文： | Lai Bao Wang Jia Pan Can Ling Tang Xiu Ren Bu Jie Wang. Microwave-prompted rapid and efficient synthesis of 3-alkyl substituted imidazo[1,5-a]pyridines[J]. 中国化学快报, 2007, 18(4): 390-392. DOI: 10.1016/j.cclet.2007.02.015 |
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| 作者姓名： | Lai Bao Wang Jia Pan Can Ling Tang Xiu Ren Bu Jie Wang |
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| 作者单位： | [1]College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China [2]Department of Chemistry, Clark Atlanta University, Atlanta, GA 30314, USA |
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| 摘 要： | Under regular heating and microwave irradiation, 3-alkyl substituted imidazo[1,5-a] pyridines were synthesized from 2,2＇- pyridil, di-2-pyridyl ketone and aliphatic aldehydes in the presence of ammonium acetate and acetic acid. Compared to the traditional heating condition, the reaction time under microwave irradiation was shorter and 3-alkyl imidazo[1,5-a]pyddines were given in higher yield.
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| 关 键 词： | 3-烷基取代咪唑[1 5-a]吡啶 微波辐射 敏捷合成 优化条件 |
| 收稿时间： | 2006-11-13 |
Microwave-prompted rapid and efficient synthesis of 3-alkyl substituted imidazo[1,5-a] pyridines |
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| Lai Bao Wang,Jia Pan,Can Ling Tang,Xiu Ren Bu,Jie Wang. Microwave-prompted rapid and efficient synthesis of 3-alkyl substituted imidazo[1,5-a] pyridines[J]. Chinese Chemical Letters, 2007, 18(4): 390-392. DOI: 10.1016/j.cclet.2007.02.015 |
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| Authors: | Lai Bao Wang Jia Pan Can Ling Tang Xiu Ren Bu Jie Wang |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China;2. Department of Chemistry, Clark Atlanta University, Atlanta, GA 30314, USA |
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| Abstract: | Under regular heating and microwave irradiation,3-alkyl substituted imidazo[1,5-a]pyridines were synthesized from 2,2'-pyridil,di-2-pyridyl ketone and aliphatic aldehydes in the presence of ammonium acetate and acetic acid.Compared to the traditional heating condition,the reaction time under microwave irradiation was shorter and 3-alkyl imidazo[1,5-a]pyridines were given in higher yield. |
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| Keywords: | Microwave irradiation 3-Alkyl imidazo[1,5-a]pyridine |
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