Acylation of Grignard reagents mediated by N-methylpyrrolidone: a remarkable selectivity for the synthesis of ketones |
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| Authors: | Gowda Maravanhalli Sidde Pande Sushanth Sudhir Ramakrishna Ramesha Andagar Prabhu Kandikere Ramaiah |
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| Affiliation: | R. L. Fine Chem, No. 15, KHB Industrial Area, Yelahanka Newtown, Bangalore, 560 106, Karnataka, India. |
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| Abstract: | An efficient user-friendly method of acylation of Grignard reagents to selectively synthesize ketones is presented, which is assisted by simple amides such as NMP, or DMF. The present chemoselective method tolerates a variety of functional groups such as ketone, ester, nitrile and other functional groups. |
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