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A Simple Synthesis Route for Selectively Methylated β-Cyclodextrin Using a Copper Complex Sandwich Protecting Strategy |
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| Authors: | Stefan Bucur Marius Niculaua Catalina Ionica Ciobanu Neculai Catalin Lungu Ionel Mangalagiu |
| Affiliation: | 1.Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania;2.Research Center of Oenology, Romanian Academy—Iași Division, 700505 Iași, Romania;3.Institute of Interdisciplinary Research–CERNESIM Centre, Alexandru Ioan Cuza University of Iasi, 700506 Iași, Romania; |
| Abstract: | This communication reports a novel synthesis route for the preparation of monofunctionalized β-cyclodextrin in a single stage. The approach involves only the in-situ protection of secondary hydroxyl groups as an excellent alternative to the classical procedure involving a series of five steps of protection and deprotection of hydroxyl groups (both primary and secondary ones) belonging to β-cyclodextrin. |
| Keywords: | cyclodextrin selective primary side substitution copper complex control of the reactivity one-pot reaction |