Synthetic Strategies in the Preparation of Phenanthridinones |
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| Authors: | Rajeshwar Reddy Aleti Alexey A Festa Leonid G Voskressensky Erik V Van der Eycken |
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| Institution: | 1.Organic Chemistry Department, Science Faculty, RUDN University, Miklukho-Maklaya St., 6, 117198 Moscow, Russia; (R.R.A.); (A.A.F.); (L.G.V.);2.Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium |
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| Abstract: | Phenanthridinones are important heterocyclic frameworks present in a variety of complex natural products, pharmaceuticals and displaying wide range of pharmacological actions. Its structural importance has evoked a great deal of interest in the domains of organic synthesis and medicinal chemistry to develop new synthetic methodologies, as well as novel compounds of pharmaceutical interest. This review focuses on the synthesis of phenanthridinone scaffolds by employing aryl-aryl, N-aryl, and biaryl coupling reactions, decarboxylative amidations, and photocatalyzed reactions. |
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| Keywords: | N-methoxy benzamides benzanilides 2-phenyl benzamides ketoximes and aldoximes C– H bond activation C– C and C– N bond activation arynes carbonylation oxidation |
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