Obstacle Effects on One-Dimensional Translocation of ATPase |
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Authors: | WANG Xian-Ju AI Bao-Quan LIU Liang-Gang |
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Institution: | Department of Physics, Zhongshan University, Guangzhou 510275, China |
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Abstract: | We apply a general random walk model to the study of the ATPase's
one-dimensional translocation along obstacle biological environment,
and show the effects of random obstacles on the ATPase translocation
along single-stranded DNA. We find that the obstacle environment can
reduce the lifetime of ATPase lattice-bound state which results in
the inhibition of ATPase activity. We also carry out the ranges of rate
constant of ATPase unidirectional translocation and bidirectional
translocation. Our results are consistent with the experiments and relevant theoretical consideration, and can be used to explain some physiological phenomena. |
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Keywords: | random walk average statistical time obstacle |
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