Constituents of Holothuroidea, 15. Isolation of ante-iso type regio-isomer on long chain base moiety of glucocerebroside from the sea cucumber Holothuria leucospilota |
| |
Authors: | Yamada Koji Wada Noriko Onaka Hiroyuki Matsubara Rei Isobe Ryuichi Inagaki Masanori Higuchi Ryuichi |
| |
Affiliation: | Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. |
| |
Abstract: | An ante-iso type regio-isomer on the long chain base moiety of a glucocerebroside, HLC-2-A, has been isolated from its parent glucocerebroside molecular species HLC-2 composed of iso and ante-iso isomers, from the less polar lipid fraction of a chloroform/methanol extract of the sea cucumber Holothuria leucospilota. Reverse-phase HPLC that included a recycling system was effective in separating the regio-isomer from its counterpart, revealing a very close resemblance in structure. Other typical glucocerebroside molecular species HLC-1 and HLC-3 were obtained together with HLC-2. The structures of these glucocerebrosides were determined on the basis of chemical and spectroscopic evidence. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|