Lipid A and related compounds. XXXVII. Determination of favorable binding linkages of lipid A analog to antigen moiety for synthetic vaccines |
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| Authors: | Ikeda K Miyajima K Shimizu T Achiwa K |
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| Institution: | School of Pharmaceutical Sciences, University of Shizuoka, Japan. |
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| Abstract: | For the determination of favorable binding linkages of lipid A analog as a synthetic immunoadjuvant to the antigen moiety for synthetic vaccines, new N-acylated L-serine-containing D-glucosamine analogs (Type A, B, C) were synthesized and their mitogenicities were examined. Among chemically synthesized compounds (6-15, 30), compound 8 for Type B exhibited the most potent mitogenicity. |
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