The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst |
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| Authors: | Hadei Niloufar Kantchev Eric Assen B O'Brien Christopher J Organ Michael G |
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| Institution: | Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada. |
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| Abstract: | The development of an NHC-based system capable of cross-coupling sp(3)-sp(3) centers in high yield has been a long-standing challenge. This communication describes the use of a Pd-NHC catalytic system that achieves room-temperature Negishi cross-couplings of unactivated, primary bromides and alkyl organozinc reagents with a variety of functionality. reaction: see text] |
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