The Effect of Oxandrolone on Voice Frequency in Growth Hormone-Treated Girls With Turner Syndrome |
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Authors: | Leonie A Menke Theo CJ Sas Sophie HL van Koningsbrugge Maria AJ de Ridder Gladys RJ Zandwijken Bart Boersma Philippe H Dejonckere Sabine MPF de Muinck Keizer-Schrama Barto J Otten Jan M Wit |
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Institution: | ∗Dutch Growth Research Foundation, Rotterdam, The Netherlands;†Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands;‡Department of Pediatrics, Albert Schweitzer Hospital, Dordrecht, The Netherlands;§Department of Pediatrics, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands;║Department of Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands;¶Department of Pediatrics, Alkmaar Medical Center, Alkmaar, The Netherlands;#Department of Phoniatrics, University Medical Center Utrecht, Utrecht, The Netherlands;∗∗Department of Pediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands |
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Abstract: | Objectives/HypothesisOxandrolone (Ox) increases height gain but may also cause voice deepening in growth hormone (GH)-treated girls with Turner syndrome (TS). We assessed the effect of Ox on objective and subjective speaking voice frequency in GH-treated girls with TS.Study DesignA multicenter, randomized, placebo (Pl)-controlled, double-blind study was conducted.MethodsOne hundred thirty-three patients were included and treated with GH (1.33 mg/m2/d) from baseline, combined with Pl or Ox in a low (0.03 mg/kg/d) or conventional (0.06 mg/kg/d) dose from the age of 8 years and estrogens from the age of 12 years. Yearly from starting Ox/Pl until 6 months after discontinuing GH + Ox/Pl, voices were recorded and questionnaires were completed.ResultsAt start, mean (±standard deviation SD]) voice frequency SD score (SDS) was high for age (1.0 ± 1.2, P < 0.001) but normal for height. Compared with GH + Pl, voices tended to lower on GH + Ox 0.03 (P = 0.09) and significantly lowered on GH + Ox 0.06 (P = 0.007). At the last measurement, voice frequency SDS was still relatively high in GH + Pl group (0.6 ± 0.7, P = 0.002) but similar to healthy girls in both GH + Ox groups. Voice frequency became lower than −2 SDS in one patient (3%) on GH + Ox 0.03 and three patients (11%) on GH + Ox 0.06. The percentage of patients reporting subjective voice deepening was similar between the dosage groups.ConclusionsUntreated girls with TS have relatively high-pitched voices. The addition of Ox to GH decreases voice frequency in a dose-dependent way. Although most voice frequencies remain within the normal range, they may occasionally become lower than −2 SDS, especially on GH + Ox 0.06 mg/kg/d. |
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Keywords: | Turner syndrome Growth hormone therapy Oxandrolone Estrogen replacement therapy Voice |
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