| 5-(4-吡啶基-1,3,4-(口恶)二唑-2-硫酮的合成和谱学研究 |
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| 引用本文： | 王瑛,严莲荷.5-(4-吡啶基-1,3,4-(口恶)二唑-2-硫酮的合成和谱学研究[J].光谱学与光谱分析,2006,26(12):2229-2231. |
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| 作者姓名： | 王瑛 严莲荷 |
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| 作者单位： | 南京理工大学化工学院,江苏,南京,210094 |
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| 摘 要： | 5-(4-吡啶基)-1,3,4-(口恶)唑-2-硫酮(C7H5N3OS)是异烟肼与二硫化碳发生加成闭环反应时获得.文章初步讨论了反应历程,提出该反应的机理是亲核加成,并通过IR谱和NMR谱对标题化合物的结构进行了表征,热稳定性测试表明:该化合物在506℃时完全分解.
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| 关 键 词： | 闭环反应 异烟肼 结构表征 |
| 文章编号： | 1000-0593（2006）12-2229-03 |
| 收稿时间： | 2005-09-28 |
| 修稿时间： | 2005-12-26 |
Study on the Spectroscopy of 5-(4-Pyridyl)-1,3,4-Oxadiazole-2-Thiol |
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| WANG Ying,YAN Lian-he.Study on the Spectroscopy of 5-(4-Pyridyl)-1,3,4-Oxadiazole-2-Thiol[J].Spectroscopy and Spectral Analysis,2006,26(12):2229-2231. |
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| Authors: | WANG Ying YAN Lian-he |
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| Institution: | Chemical Engineering School, Nanjing University of Science and Technology, Nanjing 210094, China |
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| Abstract: | The title compound (5-(4-pyridyl)-1,3,4-oxadiazole-2-thiol) was synthesized by the ring-closing reaction of isoniazide with carbon bisulfide, and the reaction course was discussed preliminarily. The mechanism of this reaction is nucleophilic addition. The compound was characterized by Fourier transform infrared (FTIR) spectrometry and nuclear magnetic resonance (NMR). The thermal analytical data indicate that the compound was decomposed completely at the temperature of 506 degrees C. |
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| Keywords: | Ring-closing reaction Isoniazide Structure characterization |
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