Stochastic resonance is applied to quantitative analysis for weak chromatographic signal of glyburide in plasma |
| |
Authors: | Wei Zhang Bingren Xiang Yanwei Wu Erxin Shang |
| |
Affiliation: | Center for Instrumental Analysis, China Pharmaceutical University, Tongjiaxiang 24, Nanjing, Jiangsu 210009, China |
| |
Abstract: | Based on the theory of stochastic resonance, a new method carried on the quantitive analysis to weak chromatographic signal of glyburide in plasma, which was embedded in the noise background and the signal-to-noise ratio (SNR) of HPLC-UV is enhanced remarkably. This method enhances the quantification limit to 1 ng ml−1, which is the same as HPLC-MS, and makes it possible to detect the weak signal accurately by HPLC-UV, which was not suitable before. The results showed good recovery and linear range from 1 to 50 ng ml−1 of glyburide in plasma and the method can be used for quantitative analysis of glyburide. |
| |
Keywords: | Stochastic resonance Glyburide Weak signal High performance liquid chromatography |
本文献已被 ScienceDirect 等数据库收录! |
|