Properties of astaxanthin/Ca2+ complex formation in the deceleration of cis/trans isomerization |
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| Authors: | Chen Chien-Sheng Wu Shih-Hsiung Wu Ying-Ying Fang Jim-Min Wu Tzu-Hua |
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| Affiliation: | Department of Chemistry, National Taiwan University, Taipei 106, Taiwan. |
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| Abstract: | Deceleration of the regioselective cis/trans isomerization of all-trans-astaxanthin (ASTX) in the presence of Ca2+ was shown by HPLC analysis. The NMR and ITC analyses provided evidence for complexation of ASTX with Ca2+ in 1:2 stoichiometry via chelation at both carbonyl and hydroxyl groups. The rotation across torsion omega6 (C5-C6-C7-C8) upon complexation is consistent with the NOE between 7-H and 5-CH3. This study supports the inhibitory effect of ASTX on calcium-induced turbidity of lens crystallins. |
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