Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush |
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| Authors: | Justin P Templeton Mohamed Nassr Felix Vazquez-Chona Natalie E Freeman-Anderson William E Orr Robert W Williams Eldon E Geisert |
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| Institution: | (1) Department of Ophthalmology, University of Tennessee Health Science Center, 38163 Memphis, TN, USA;(2) Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 38163 Memphis, TN, USA |
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| Abstract: | Background Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation
in the time course and severity of RGC loss. Indeed, this process appears to be influenced by a wide variety of genetic and
environmental factors. In this study we explored the genetic basis for differences in ganglion cell death in two inbred strains
of mice. |
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