Derivatization of organophosphorus nerve agent degradation products for gas chromatography with ICPMS and TOF-MS detection |
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Authors: | Douglas D Richardson Joseph A Caruso |
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Institution: | (1) Department of Chemistry, McMicken College of Arts and Sciences, University of Cincinnati, Cincinnati, OH 45221-0172, USA |
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Abstract: | Separation and detection of seven V-type (venomous) and G-type (German) organophosphorus nerve agent degradation products
by gas chromatography with inductively coupled plasma mass spectrometry (GC–ICPMS) is described. The nonvolatile alkyl phosphonic
acid degradation products of interest included ethyl methylphosphonic acid (EMPA, VX acid), isopropyl methylphosphonic acid
(IMPA, GB acid), ethyl hydrogen dimethylamidophosphate sodium salt (EDPA, GA acid), isobutyl hydrogen methylphosphonate (IBMPA,
RVX acid), as well as pinacolyl methylphosphonic acid (PMPA), methylphosphonic acid (MPA), and cyclohexyl methylphosphonic
acid (CMPA, GF acid). N-(tert-Butyldimethylsilyl)-N-methyltrifluroacetamide with 1% TBDMSCl was utilized to form the volatile TBDMS derivatives of the nerve agent degradation
products for separation by GC. Exact mass confirmation of the formation of six of the TBDMS derivatives was obtained by GC–time
of flight mass spectrometry (TOF-MS). The method developed here allowed for the separation and detection of all seven TBDMS
derivatives as well as phosphate in less than ten minutes. Detection limits for the developed method were less than 5 pg with
retention times and peak area precisions of less than 0.01 and 6%, respectively. This method was successfully applied to river
water and soil matrices. To date this is the first work describing the analysis of chemical warfare agent (CWA) degradation
products by GC–ICPMS.
Figure Illustrated here are six parent organophosphorus nerve agents corresponding to the degradation products analyzed by gas chromatography
with ICPMS and ToF-MS detection. The authors would like to thank Daisy-Malloy Hamburg and Kevin M. Kubachka for creating this
figure |
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Keywords: | GC Mass spectrometry/ICP– MS Derivatization Chemical warfare agent degradation products |
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