Effect of fluorinated tetrahydrocarbazole derivatives on the enzymes of oxidative deamination of biogenic amines and on the process of lipid peroxidation |
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Authors: | N. S. Nikolaeva Yu. V. Soldatova A. V. Smolina A. Yu. Aksinenko V. B. Sokolov A. S. Kinzirsky R. A. Kotel´nikova V. N. Shtolko A. I. Kotel´nikov |
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Affiliation: | 1.Institute of Physiologically Active Compounds of the Russian Academy of Sciences,Chernogolovka, Moscow region,Russian Federation;2.Institute of Problems of Chemical Physics of the Russian Academy of Sciences,Chernogolovka, Moscow region,Russian Federation |
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Abstract: | The effect of two fluorinated derivatives of tetrahydrocarbazoles on mitochondrial en-zymes catalyzing the oxidative deamination of biogenic amines such as monoamine oxidase A and B (MAO-A and MAO-B) has been investigated. A dose-dependent effect of the studied compounds on the enzymatic activity MAO-A was shown. It was revealed that both com-pounds are MAO-B inhibitors. Inhibition mechanisms were established and MAO-B inhibi-tion constants were calculated. The above derivatives exhibit strong antioxidant and antirad-ical activity. |
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