Intramolecular PIFA-mediated alkyne amidation and carboxylation reaction |
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Authors: | Tellitu Imanol Serna Sonia Herrero M Teresa Moreno Isabel Domínguez Esther SanMartin Raul |
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Institution: | Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain. imanol.tellitu@ehu.es |
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Abstract: | The hypervalent iodine reagent PIFA promotes the intramolecular electrophilic cyclization of easily accessible alkynylamides and alkynyl carboxylic acids, leading to the formation of pyrrolidinone and lactone skeletons, respectively, in a very efficient way. A synthetic study and a mechanistic proposal for these transformations are presented. |
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