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Rational design of cationic cyclooligosaccharides as efficient gene delivery systems |
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| Authors: | Díaz-Moscoso Alejandro Balbuena Patricia Gómez-García Marta Ortiz Mellet Carmen Benito Juan M Le Gourriérec Loïc Di Giorgio Christophe Vierling Pierre Mazzaglia Antonino Micali Norberto Defaye Jacques García Fernández José M |
| Affiliation: | Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092, Sevilla, Spain. |
| Abstract: | Self-assembled cyclodextrin (CD)-DNA nanoparticles (CDplexes) exhibiting transfection efficiencies significantly higher than PEI-based polyplexes have been prepared from homogeneous seven-fold symmetric polyaminothiourea amphiphiles constructed on a beta-cyclodextrin scaffold. |
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