Cholesterol-induced modulated phase in phospholipid membranes |
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Authors: | Karmakar Sanat Raghunathan V A |
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Affiliation: | Raman Research Institute, Bangalore 560 080, India. sanat@rri.res.in |
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Abstract: | We report the observation of a cholesterol-induced modulated phase (Pbeta) in dipalmitoyl phosphatidylcholine bilayers. It occurs below the main transition of the lipid at cholesterol concentrations of around 15 to 20 mol % and is distinct from the ripple (Pbeta') phase found in between the main and pretransitions at lower cholesterol concentrations. An electron density map of this phase, constructed from x-ray diffraction data from oriented multilayers, shows that the bilayers in this phase have a one-dimensional periodic height modulation with an amplitude of about 2.5 A. A partial phase diagram of the system deduced from diffraction data is in broad agreement with earlier studies. |
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