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Toward the optimization of continuous-flow aldol and α-amination reactions by means of proline-functionalized silicon packed-bed microreactors |
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| Authors: | Alessandro Massi Alberto CavazziniOmar Pandoli Valentina CostaLuisa Pasti Pier Paolo Giovannini |
| Institution: | a Dipartimento di Chimica, Università di Ferrara, Via L. Borsari 46, I-44121 Ferrara, Italy b National Key Laboratory of Micro/Nano Fabrication Technology, Shanghai Jiao Tong University, Shanghai, PR China c Dipartimento di Biologia ed Evoluzione, Università di Ferrara, Corso Ercole I D’Este 32, I-44121 Ferrara, Italy |
| Abstract: | The activity and stability under flow conditions of covalently and non-covalently silica supported proline and proline-like organocatalysts is herein described. The slow aldol reaction of cyclohexanone with p-nitro benzaldehyde and the fast α-amination of isovaleraldehyde with dibenzyl azodicarboxylate have been selected as model reactions for this study. Prospects and limitations of the disclosed continuous-flow organocatalytic approach are widely discussed. |
| Keywords: | Asymmetric catalysis Continuous-flow processes Microreactors Organocatalysis |
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