New route synthesis of indolizines via 1,3-dipolar cycloaddition of pyridiniums and alkynes |
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| Authors: | Yongjia Shang Min Zhang Shuyan Yu Kai Ju Cuie Wang Xinwei He |
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| Affiliation: | Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China |
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| Abstract: | A convenient synthesis of 2,3-di and 1,2,3-trisubstituted indolizines has been achieved via a 1,3-dipolar cycloaddition of pyridiniums and alkynes. Various alkynes and diynes were used instead of dimethyl acetylenedicarboxylate (DMAD) and its analogues in the traditional method. The corresponding 1,2,3-trisubstituted indolizines are useful building blocks for the construction of complex indolizine derivatives. |
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| Keywords: | Indolizine 1,3-Dipolar cycloaddition Bridgehead N-heterocycles Alkyne Diyne |
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