Palladium/acetic acid-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones as pronucleophiles |
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| Authors: | Chuanfa Ni |
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| Institution: | Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China |
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| Abstract: | A facile palladium-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones in the presence of acetic acid has been achieved. By using different α-substituted fluoro(phenylsulfonyl)methane derivatives, a variety of allylated monofluoromethyl compounds were obtained with high regio- and stereoselectivity. Substrate scope and limitation were also examined, and it was found that the reaction was amenable to both 1-aryl-substituted propynes and 3-aryl-substituted propynyl ethers. |
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| Keywords: | Fluoromethylation Allylation Alkyne Palladium Synthetic method |
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