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Microwaves enhance cyclisation of tetrapeptides |
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| Authors: | Elena Cini Manuela Rodriquez |
| Institution: | a Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy b Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Salerno, Italy |
| Abstract: | Head-to-tail cyclisation tetrapeptides can be improved using microwave dielectric heating. Cyclisation occurs rapidly at millimolar dilution giving the product in higher purity and yields if compared with standard conditions. The reaction can be applied to sequences containing at least one d-amino acid. |
| Keywords: | Microwaves Cyclopeptides Solid-phase synthesis |
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