Synthesis of β-hydroxymalonates: the direct aldol addition of malonates to aldehydes in the presence of SiCl4 and i-Pr2EtN |
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| Authors: | Antonio Massa Arrigo Scettri Laura Capozzolo |
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| Institution: | a Dipartimento di Chimica, Università di Salerno, Via Ponte Don Melillo 84084, Fisciano (SA), Italy
b Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo 84084, Fisciano (SA), Italy |
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| Abstract: | The direct aldol addition of malonates to aromatic, hetero-aromatic and unsaturated aldehydes leading to β-hydroxymalonates is described. The stability of these products, the trimethyl silyl protection of the hydroxyl group as well as the role of both SiCl4 and i-Pr2EtN in attaining the final products are also discussed. |
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| Keywords: | Aldol addition Malonate SiCl4 i-Pr2EtN β-Hydroxymalonate |
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