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A mild and efficient method for the reduction of nitriles |
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| Authors: | Sté phane Laval,Alain Favre-Reguillon,Mikaë l Berthod,Gé rard Mignani |
| Affiliation: | a Laboratoire de Catalyse et Synthèse Organique, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), CNRS, UMR5246, Université Lyon 1, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France b Laboratoire de Transformations Chimiques et Pharmaceutiques, UMR7084, Conservatoire National des Arts et Métiers, 2 Rue Conté, 75003 Paris, France c Minakem SAS, 145 Chemin des Lilas, 59310 Beuvry la Foret, France d Rhodia, Lyon Research center, 85, Avenue des Frères Perret, BP 62, 69192 Saint-Fons Cedex, France |
| Abstract: | A simple and useful method for the reduction of nitriles into the corresponding amines using a tetramethyldisiloxane/titanium(IV) isopropoxide reducing system is described. The synthetic approach is straightforward and provides primary amines as hydrochloride salt in almost quantitative yield. Other advantages of this method, such as easy-to-handle hydride source, inert by-products, that is, TiO2 and oligomeric siloxanes, make it very attractive to prepare primary amines. |
| Keywords: | Amines Tetramethyldisiloxane Titanium Reduction Nitriles |
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