One-step, three-component synthesis of highly substituted pyridines using silica nanoparticle as reusable catalyst |
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Authors: | Subhash Banerjee Grigoriy Sereda |
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Institution: | University of South Dakota, Department of Chemistry, 414 E. Clark Street, Vermillion, SD 57069, United States |
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Abstract: | One-step synthesis of ‘privileged medicinal scaffolds’, 2-amino-3,5-dicarbonitrile- 6-sulfanylpyridines, has been demonstrated via a multicomponent reaction of aldehydes, malononitrile, and thiols using silica nanoparticle (NP) as catalysts. The silica NP catalysts are very mild (nearly neutral in nature), effective, environmentally benign, and retain most of their activities after being reused for three times. |
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Keywords: | 2-Amino-3 5-dicarbonitrile-6-sulfanylpyridines Multicomponent reaction Silica nanoparticles Catalysis |
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