|
|||||
|
|
Novel ninhydrin adduct of catechin with potent antioxidative activity |
|
| Authors: | Kiyoshi Fukuhara Akiko Ohno Kohei Imai Kazunori Anzai Haruhiro Okuda |
| Affiliation: | a Division of Organic Chemistry, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan b Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan c Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency, Suita, Osaka 565-0871, Japan d Department of Applied Chemistry, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama-shi, Saitama 337-8570, Japan e Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Aichi 467-8603, Japan |
| Abstract: | The reaction of ninhydrin with (+)-catechin in the presence of TMSOTf resulted in condensation product 1, which consists of a 2:1 mixture of epimers at the C-2 position. The antioxidative radical-scavenging activity of 1 against the galvinoxyl radical, acting as an oxyl radical, was significantly enhanced compared to (+)-catechin. Our results offer a new method for chemical modification of a natural phenolic antioxidant. |
| Keywords: | Catechin Antioxidant Ninhydrin Galvinoxyl radical Radical scavenging |
| 本文献已被 ScienceDirect 等数据库收录！ | |