Deprotonation and regioselective addition of 2H-pyrazolo[3,4-c]quinolines to electrophiles |
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| Authors: | Danielson Michael E Hays David S Kshirsagar Tushar A Haraldson Chad A Lundquist Gregory D Wurst Joshua R Lindstrom Kyle J Mackey Sonja S Willie Daniel J Heppner Philip D Leir Charles M Benson Karl E |
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| Affiliation: | 3M Pharmaceuticals, 3M Center, Building 270-4S-02, St. Paul, Minnesota 55144-1000, USA. mdanielson@biotherapharma.com |
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| Abstract: | The deprotonation and regioselective reaction of 2H-pyrazolo[3,4-c]quinolines with a variety of electrophiles is described. Electrophiles include benzaldehyde, DMF, carbon dioxide, and iodine. This method provides a direct route to a class of pharmacologically interesting compounds. |
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