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Enantiomeric separation of halocarboxylic acids by capillary gas chromatography |
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| Authors: | E Koch G J Nicholson E Bayer |
| Abstract: | The direct determination of the enantiomeric purity of halocarboxylic acids is described. The method used involves gas chromatographic separation of the corresponding tert-butylamides on deactivated glass or fused-silica capillaries coated with Chirasil-Val. Both the influence of the amide moiety on enantiomeric resolution and tailing, and the racemization during formation of the amide derivatives were studied. |
| Keywords: | Capillary gas chromatography Enantiomeric separation Racemization Halocarboxylic acids Amide derivatives |