| Abstract: | Three bidesmosidic saponins ( 1–3 ) have been isolated from the methanolic extract of the berries of Phytolacca dodecandra l'HERIT (Phytolaccaceae) by a combination of rotation locular counter-current chromatography and column chromatography on reversed phase (RP-8) With MeOH/H2O. The structures have been established by 1H-NMR, 13C-NMR, FAB-MS, and D/CI-MS, as well as on the basis of acidic and basic hydrolyses. The monodesmosidic saponins 1a–3a obtained after partial hydrolysis with a base exhibit strong molluscicidal activity against the schistosomiasis-transmitting snail Biomphalaria glabrata. Saponins 1–3, 1a , and 3a are reported for the first time, whereas 2a has been identified previously in the aqueous extract of P. dodecandra berries. |
