Singlet oxygen formation in monomeric and aggregated porphyrin c |
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Authors: | L E Bennett K P Ghiggino R W Henderson |
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Institution: | Department of Physical Chemistry, University of Melbourne, Victoria, Australia. |
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Abstract: | The absorption and fluorescence spectra of monomeric and aggregated species present in aqueous solutions of porphyrin c have been resolved by steady-state and time-resolved spectroscopy. The dependence of the singlet oxygen formation yield (phi delta) on excitation wavelength has also been determined. In the Q-band spectral region, the aggregate absorption and emission spectra are shifted to longer wavelengths with respect to the monomer spectrum with phi delta (monomer) = 0.59 and phi delta (aggregate) = 0.33. The relevance of these findings to the optimization of irradiation conditions in tumour phototherapy using porphyrin c are discussed. |
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