A novel approach to the synthesis of 5-trifluoromethyl-3-substituted pyrazoles |
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| Authors: | A KrishnaiahB Narsaiah |
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| Institution: | Organic Chemistry Division II, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | The 3-cyano-4-trifluoromethyl-6-phenyl or substituted phenyl 2(1H) pyridones (1) on reaction with hydrazine hydrate, gave exclusively in 5-trifluoromethyl-3-substituted pyrazoles (3) through a novel method. A possible mechanistic pathway for change in the site of nucleophilic attack due to the CF3 group in 2(1H) pyridones is described. |
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| Keywords: | 2(1H) pyridones Bis-nucleophiles Pyrazoles |
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